Zahedan Journal of Research in Medical Sciences
Volume:20 Issue: 10, Oct 2018

The impaired adipocytes secrete factors observed in diabetes contribute to insulin resistance. The purpose of the present study was to compare the effects of high-intensity interval versus moderate intensity combined resistance and aerobic training on some adipokines related to insulin resistance (interleukin-6 [IL-6], apelin, and monocyte chemoattractant protein 1 (MCP-1)) in women with type 2 diabetes.

Fifty two females with type 2 diabetes (aged 45 - 60 years, the HbA1C value of 6.5% or above, and fasting blood glucose ≥ 126 mg/dL (7.0 mmol/L)) were assessed for eligibility. The participants were assigned to a HIIT group (n = 17), a combined resistance and aerobic training group (n = 17), and a control group (n = 18) randomly. The exercises included 10 weeks of combined training and HIIT.

TNF-α concentrations changed significantly in the HIIT (P = 0.001) and combined training (P = 0.015) groups. The same test revealed that the differences were significant for the IL-6 in the HIIT (P < 0.000) and combined training (P < 0.000) groups. Data also showed significant differences in MCP-1 and IL-6 levels in the HIIT and combined resistance and aerobic training groups (P < 0.05). In addition, there were no significant changes in apelin in both groups after 10 weeks (P > 0.05). The ANCOVA test showed no significant differences in apelin (F = 0.511, P = 0.12).

The results highlight that exercise training, independent of the mode of training, is an effective strategy to improve some adipokines related to insulin resistance in women with type 2 diabetes

In the recent years, many studies have been done on the drug combination of ketamine and propofol (ketofol). Ketamine, due to increase in blood pressure, improves hemodynamic changes of propofol. On the other hand, propofol has antiemetic effects and through strong sedative effect reduces the psychiatric side effects of ketamine. Studies have used the combination of propofol and ketamine (within a syringe) as a new drug called ketofol.

Because of the possible drug interactions between these two drugs, this study was conducted to compare the effects of ketofol with the effect of ketamine plus propofol on hemodynamic status of patients undergoing transurethral lithotripsy (TUL).

This quasi-experimental study was carried out on patients undergoing TUL, during year 2015. After considering the inclusion and exclusion criteria, the sample size for each group was determined as 20 subjects, who were randomly assigned to one of the treatment groups. In the patients of the ketofol group, 1 mg/kg of propofol and 1 mg/kg of ketamine were drawn in a syringe and then injected. In the patients of ketamine plus propofol group, 1 mg/kg of propofol and 1 mg/kg of ketamine was drawn in separate syringes and were injected consecutively. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and arterial blood oxygen-saturated hemoglobin (O2Sat) were recorded at 1, 5, 10 and 15 minutes after endotracheal intubation. Data was analyzed using descriptive and analytical statistics (mean, frequency, and Independent t-test).

Males constituted 75% of patients. The mean age of participants was 37.34 ± 8.33 years and the age group of 31 to 45 years accounted for the highest percentage. There were no significant differences in mean ± SD of SBP, DBP, MAP, HR, and O2Sat at different times of surgery in the groups of ketofol and ketamine plus propofol.

According to the non-significant mean SBP, DBP, MAP, HR, and O2Sat at different times of surgery in the groups of ketofol and ketamine plus propofol, there is no need to combine the two drugs. Thus, possible complications and drug interactions of the combination of ketamine and propofol can be prevented (ketofol)

Drug addiction is a painful fact especially in the youth population. It is one of the main social, economic and hygienic problem, which has negative effects on the human life. Therefore, finding predisposing factors of addiction can help decrease this phenomenon. Family function and sensation seeking are two factors that seems to play a role in tendency towards drug abuse. Thus, the main purpose of this study was to investigate the relationship among tendency towards drug abuse, family function, and sensation seeking in university students and gender differences in prediction of tendency towards drug abuse.

In this descriptive-correlational study, a total of 350 university students were selected by the convenience sampling method in Yazd University. They were evaluated by Addiction Potential Scale (Weed, 1992), Family Assessment Device Scale (McMaster, 1983), and Sensation Seeking Scale (Zukerman, 1968). Data analysis was done by Regression Analysis.

Findings showed that family function among female students and sensation seeking among male students is significantly related to the tendency towards drug abuse (P < 0.05); in addition, regression analysis showed that roles subscale of family function among female respondents and adventure subscale of sensation seeking among male respondents were predictors of tendency towards drug.

This study showed that sensation seeking as a personality factor and family function as an environmental factor can effect on student’s tendency towards drug.

We present a case of rudimentary horn pregnancy in the 18th gestational week with fetal demise and treatment failure. After failure in pregnancy termination, the patient was admitted to a tertiary care hospital. Following laparatomy, a definitive diagnosis was confirmed. Laparotomy was performed to remove the rudimentary horn and ipsilateral fallopian tube. Overall, physicians should be cautious about the risk of uterine disorders in the event of several failures in terminating pregnancy